ethyl (2S,3S)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate

Name	(2S,3S)-trans-epoxysuccinyl-L-*leucylamido-3-meth
Synonyms	EST E64d E-64d Estate oxistatin E64d,E-64d aloxistatin E-64-D(LOXISTATINE) (2S,3S)-trans-epoxysuccinyl-L-*leucylamido-3-meth E-64(Trans-Epoxysuccinyl-L-Leucylamido-(4-Guanidino)Butane) (2S,3S)-trans-Epoxysuccinyl-L-leucylaMido-3-Methylbutane ethyl ester, EST ethyl (2S,3S)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate (2S,3S)-ethyl 3-(((S)-1-(isopentylaMino)-4-Methyl-1-oxopentan-2-yl)carbaMoyl)oxirane-2-carboxylate ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-Methylbutyl)aMino]carbonyl]butyl]aMino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
CAS	88321-09-9
InChI	InChI=1/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12?,13-,14-/m0/s1

Molecular Formula	C17H30N2O5
Molar Mass	342.43
Density	1.0657 (rough estimate)
Melting Point	126.2°C
Boling Point	477.88°C (rough estimate)
Flash Point	279.2°C
Solubility	Soluble in DMSO, DMF or ethanol
Vapor Presure	1.2E-11mmHg at 25°C
Appearance	White solid
Color	Fine needles from EtOH
Storage Condition	-20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Refractive Index	1.5800 (estimate)
MDL	MFCD00132883
Use	Irreversible cysteine acid protease inhibitor, lysosomal cysteine protease membrane penetration inhibitor, is also a membrane penetrating calcium activated neutral protease inhibitor. The storage solution can be stored at-20oC for six months.
In vitro study	Aloxistatin can enter intact platelets and inhibit proteolysis by inhibiting calpain. Aloxistatin attenuates parathyroid hormone-induced cell proliferation and inhibits osteoblast differentiation in vitro.
In vivo study	Aloxistatin (100 mg/kg, p.o.) strongly inhibited cathepsin B & L activity in hamster skeletal muscle, heart and liver. In rats with spinal cord injury (SCI), Aloxistatin provides neuroprotection in SCI lesions and penumbra. In animal models of Alzheimer's disease, Aloxistatin reduced brain amyloid-beta by inhibiting cathepsin B activity and improved memory impairment.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes.
UN IDs	3077
WGK Germany	2
RTECS	RR0404300
HS Code	29242990
Toxicity	cyt-ham:lng 200 mg/L IYKEDH 17,815,86

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Product Name: E-64d Visit Supplier Webpage Request for quotation
CAS: 88321-09-9
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Mobile: 18021002903
QQ: 3008007409

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ethyl (2S,3S)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate Request for Quotation